For individuals who have tried multiple antidepressants with little to no success, Spravato® (esketamine nasal spray) represents a breakthrough in mental health care. Approved by the FDA, Spravato® offers fast-acting relief for those with treatment-resistant depression. In this article, we’ll explain what Spravato® is, how it works, and whether it might be the right option for you or a loved one.
What Is Spravato®?
Spravato® is the brand name for esketamine, a nasal spray form of ketamine approved for adults with major depressive disorder (MDD) who haven’t responded to at least two other antidepressant treatments. Unlike traditional antidepressants that can take weeks to take effect, Spravato® works rapidly—often within hours or days—to relieve depressive symptoms.
How Does Spravato® Work?
Spravato® targets glutamate, a key neurotransmitter in the brain responsible for learning, memory, and mood. By acting on the NMDA receptor, Spravato® helps restore synaptic connections in the brain—essentially rewiring areas that have been damaged by chronic depression. This makes it particularly effective for patients who have not found relief through standard treatments.
Who Is Spravato® For?
Spravato® is specifically designed for adults with:
- Treatment-resistant depression (TRD): When at least two antidepressants have failed to provide relief.
- Major depressive disorder with suicidal thoughts: Spravato® can be used alongside oral antidepressants to stabilize mood quickly in crisis situations.
At Beth Psychiatry, our providers assess your medical and mental health history to determine if Spravato® is a good fit for your treatment plan.
What to Expect During Spravato® Treatment
Spravato® is administered in a clinical setting under medical supervision. Here’s what you can expect:
- Dosage: You will self-administer the nasal spray under a provider’s supervision.
- Observation: After dosing, you’ll stay in the office for at least two hours for monitoring due to potential short-term side effects such as dizziness or dissociation.
- Treatment schedule: Spravato®(esketamine nasal spray) is typically given twice a week for the first month, then once a week or less frequently as maintenance.
Learn more about Spravato and other advanced treatment options we offer at Beth Psychiatry.
Benefits of Spravato®
- Rapid relief: Many patients feel improvement within hours to days of their first dose.
- Alternative for medication-resistant depression: Offers hope to individuals who haven’t responded to other treatments.
- Improved brain function: Helps restore connections between brain cells that regulate mood and emotion.
Are There Side Effects?
Like all medications, Spravato® comes with potential side effects. These may include:
- Dizziness
- Dissociation (feeling disconnected from self or surroundings)
- Nausea
- Increased blood pressure (temporary)
These effects are monitored closely during each treatment session. Most side effects subside shortly after the session ends.
Is Spravato® Covered by Insurance?
Many insurance plans cover Spravato® (esketamine nasal spray) for patients with treatment-resistant depression. Our team at Beth Psychiatry will help you verify insurance eligibility and guide you through the approval process.
Conclusion
Spravato® represents a new era in treating depression—one that provides rapid, effective relief for those who’ve struggled for far too long. If you or a loved one is battling treatment-resistant depression, book an appointment today with Beth Psychiatry to learn if Spravato® could be the right solution for you.
FAQs
1. How fast does Spravato® work?
Many patients report improvement in mood within hours or days after their first few doses.
2. Where is the Spravato® treatment administered?
In-clinic, under the supervision of licensed medical professionals.
3. Do I need to take other medications with Spravato®?
Yes, Spravato® is used alongside a daily oral antidepressant. Your psychiatrist will create a customized plan for you.
4. Is Spravato® safe?
Spravato® is FDA-approved and has been shown to be safe when administered under medical supervision.
5. How is Spravato® different from regular ketamine therapy?
Spravato® is a specific, FDA-approved form of ketamine delivered as a nasal spray and monitored in a clinical setting.
6. How do I get started with Spravato® treatment?
Contact Beth Psychiatry to schedule a consultation and determine if Spravato® (esketamine nasal spray) is right for your treatment plan.
